Gut Health, IBS, and Innovations in Gut-Brain Disease

Alexander Martinez is the CEO and Co-Founder of Intrinsic Medicine and a former Silicon Valley corporate lawyer turned biotechnology entrepreneur. His thorough understanding of the industry and areas for improvement, in parallel with his own patient journey, inspired him to make a public health impact and seek novel medicines for broad patient populations that have been previously underserved by the traditional pharmaceutical industry. Intrinsic Medicine is a therapeutics company leveraging human milk biology to transform irritable bowel syndrome (IBS) and other Gut-Brain Axis (GBA) disorders.

Download and listen to this episode here or wherever you get podcasts!

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Five Common Myths About Mental Health

As we continue to suffer from a growing epidemic of mental illness in this country, and creating awareness is trending, we must take time to re-evaluate the way we handle this mental health conversation. As renowned psychiatrist Dr. Daniel Amen often says, mental health outcomes haven’t changed since the 1950s. Treatment options appear to be limited, because while we have plenty of medications, cases are skyrocketing.

However, there are new discussions happening, and a growing number of practitioners are seeking to support mental health with tools that were previously brushed aside. In order to move forward in our thinking about mental health, we need to dispel the myths that are often perpetuated by antiquated mentality on the topic.

Warning: some of these will be tough pills to swallow (pun intended), but they are all backed by the latest research. Please drop me a line if anything is questionable to you or you need further clarification. I’d love to have a longer discussion on the topic.

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Researching the Research: Are We Asking the Right Questions?

In order to be my own health advocate and find healing, I had to learn to question everything. I take everything I am told and run it through a lens of skepticism, then critical analysis. This recent podcast episode may fall under the umbrella of “too controversial” for some listeners, but if you’re going to draw a dividing line and say you are “pro” or “anti” anything, you better know what you’re up against.

I never want to persuade anyone to change their beliefs on any matter. But I do want to encourage questioning and a deeper look into all sides of an issue. As of now, we still have freedom to choose what is best for our own bodies and our own health. Nobody can tell you what your body needs like you intuitively can.

Which leads into the episode (which you can listen to here or find wherever you get podcasts)…

He is a pioneer of research on the gut-brain connection and had a moral obligation to his patients. Because of it, he lost everything. Now, Andy Wakefield is an award-winning filmmaker with three thought-provoking films highlighting disparities in medical treatment for the medically injured and marginalized.

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The Gut-Brain Connection and What You Can Do About It

We are in the middle of a mental illness epidemic. According to a report done by the CDC in June, 25% of people between the ages of 18-24 seriously have considered suicide since March. The percentage was 16% for adults 25-44. 31% of all age groups reported experiencing anxiety or depressive disorder, and over 40% experienced adverse or behavioral health symptoms. “The prevalence of symptoms of anxiety disorder was approximately three times those reported in the second quarter of 2019 (25.5% versus 8.1%), and prevalence of depressive disorder was approximately four times that reported in the second quarter of 2019 (24.3% versus 6.5%) (2).” See full report here.  

These numbers affect me on a very personal level.

I was diagnosed with PTSD at a young age, followed by depression, followed by a diagnosis of bipolar disorder by the time I was 18. I was on many different medications to attempt to treat my mental disconnect, and while some of the worked, some did more harm than good. I understand what it is like to experience the deepest of lows and the highest of highs. I know what it feels like to have a brain that you can’t control, a mind that races and thoughts that spin around and threaten any kind of peace or stability.

One thing I have learned, in my last decade of mental stability, is that our mental health symptoms are always responses to an imbalance in our internal or external environment. External triggers could be grief, stress, or lifestyle disruption. Internal triggers could be something like blood sugar issues, thyroid dysfunction, nutrient deficiencies… or poor gut health. Learning about the gut/brain connection and addressing key areas in my physical health made a huge impact on my mental health.

Now, there is no one size fits all. What worked for me is not going to work exactly the same in someone else. But I do believe everyone can benefit from improving gut health.

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In a perfect world, the lining of the intestine allows entry to nutrients from our food to be absorbed and go where they’re needed. This lining is supposed to prevent toxins, bacterial overgrowth, and food products from exiting the gut lining. Unfortunately, it doesn’t always work that way. When you have poor gut health, thanks to stress, toxins in the environment, overconsumption of sugar and processed foods, overuse of antibiotics or other common medications, and a whole lot of other triggers, the intestinal barrier becomes permeable, and endotoxins leak out. This is what the phrase “leaky gut” refers to. The inflammation that results leads to a myriad of health issues, but what is being studied a lot right now is the effect on the brain and mental health. Many psychiatrists are suggesting that poor gut health is at the root of many of our mental illnesses.

To further that point, it’s important to note that over 90% of our serotonin (the “happy” neurotransmitter) is produced in the gut, and serotonin cannot be produced without the assistance of amino acids. So if what we eat impacts the way our neurotransmitters are produced, it stands to reason that what we eat impacts the way our brains receive neurotransmitters and find mental wealth.

There are many lifestyle interventions that are FREE, that can benefit our brain function as well as our gut. To break it down in the most simple form possible, here’s the acronym LIVE to help you get started and give you some practical ways to start taking nourishing your gut and brain together!

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