Nature’s Ozempic.
This is the kind of clickbait title getting all sorts of attention on social media these days. Is it really possible to mimic the actions of a GLP-1 receptor agonist (like Ozempic) with supplements?
The answer is yes and no.
Let’s break down what these wonder drugs do. Because let’s be real–they’re truly amazing.
First, we need to understand GLP-1. GLP-1 stands for glucagon-like-peptide-1, which is secreted in our gut in response to food and helps us manage blood sugar and regulate appetite and satiety. We lose the ability to produce it as we age, experience loss of diversity in the gut microbiome, eat too many refined carbs and sugars, get exposed to chronic stress and toxins, and/or have a history of chronic restrictive dieting.
The medications (Ozempic, Semaglutide, Monjauro, Terzepatide, etc.) bind to and activate the GLP-1 receptor, slightly delaying gastric emptying which lowers post-meal glucose as well as fasting glucose. The effects are pretty fascinating: less preoccupation with food, decreased cravings, feeling fuller faster, and of course, rapid weight loss.
Now I’ve gotten a LOT of questions about my personal opinions on this intervention, so I’m planning on addressing this at length on a future podcast episode. Like most things, I see both sides, and I want to be able to address things well and thoughtfully. I don’t have time (or space) to get into it on this newsletter, and I’m still researching.
Back to the clickbait question: Is there such a thing as Nature’s Ozempic?
Companies are promoting the supplement berberine as an alternative to GLP-1 medications. Berberine is an incredible supplement. Some studies show it may be as effective as Metformin for lowering blood sugar levels, but I primarily use it to support people with gut overgrowths and chronic stress (which is high glycemic). Berberine is effective for gut healing AND blood sugar balance, but it doesn’t lend the same rapid weight loss results as the drugs.
So, because berberine can decrease the post-meal spike of glucose and even out the curve some, it is being promoted as Nature’s Ozempic. While it may potentially lead to weight loss in the long-term as a side effect of supporting blood sugar and the gut microbiome, it doesn’t use the same mechanism of action. And it doesn’t bring the same results as the popular drugs.
Here’s the cool news: there are LOTS of tools that can support blood sugar levels, increase satiety, and reduce “food noise” long-term. Personally, I haven’t experienced “food noise” in over ten years, when I introduced products to support my gut (especially with this combo here).

Here are my favorite tools that lead to stable blood sugar and decreased cravings! (Bonus: if you are taking any of the GLP-1 agonists for weight loss reasons, these tools can help you decrease the likelihood of gaining weight if/when you choose to stop taking them.)
- Consume at least 30 grams of protein at every meal.
- Eat your meals in this order: veggies first, protein/fat second, starches last.
- Try a tablespoon of apple cider vinegar in water before a meal.
- Eat at least 25 grams of fiber per day (go easy, it can cause digestive issues if you’re not used to it). Soluble fiber like fruits, veggies, legumes, flaxseeds, and chia seeds can be especially supportive.
- Try not to consume more than 25 grams of added sugar in a day.
- Add healthy fats to your diet like avocados and olives.
- Move your body for 10 minutes after a meal.
Supplements that are helpful: berberine, curcumin, green tea, psyllium husk, and digestive bitters (see my favorite brand and get 10% off with the code spark here). Always check with a knowledgeable practitioner before choosing to supplement with vitamins or herbs. Some interactions can occur with medications, so play it safe and find someone trained in supplements to walk you through it (like me).
Final reminder: I am not a diet coach. I don’t help people lose weight. I help people restore safety to the body through nutrients. When blood sugar is more stable, YOU feel more stable. When you’re on a blood sugar roller coaster all day, you’ll struggle with more cravings and less managed moods. Restoring safety to the body with these tips above is helpful for anyone!
*This article comes straight from my monthly newsletter. Every month, I send out meal plans, recipes, and quick tips like this one! For more like this, sign up for my monthly newsletter here.








