New Research on the Serotonin Theory of Depression – My Takeaways

The serotonin theory of depression has been extremely pervasive in how we discuss mental health, though no comprehensive review has ever fully broken down the relevant evidence. 

At first glance, the selective serotonin reuptake inhibitor (SSRI) method of keeping serotonin in our synapses longer is pretty revolutionary.

But that’s assuming that an issue with serotonin at the brain level is what is causing depression.

Unfortunately, current research is showing that depression and mood issues are not simply related to serotonin alone. There are MANY other factors at play, chronic inflammation being a key role, along with other epigenetic drivers.

While over 77 million Americans are prescribed psychotropic drugs in the US (which is a number greater than any other developed country), with 45 million on antidepressants, we still have climbing rates of depression and anxiety, and prescriptions are being written for children as young as two. 

A new systematic review and meta-analysis, published this week in Molecular Psychiatry, suggests that depression isn’t a chemical imbalance of serotonin or really anything to do with low serotonin at all.

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Being Med-Free: My 4 Year Anniversary

They told me I’d need medication the rest of my life.

4 years ago this week, I was weaned off my last medication, 10 milligrams of Celexa. I had vertigo for 3 weeks. Some days I felt like I was riding a roller coaster. After 18 years of being medicated, it wasn’t an easy transition for my body.

My doctor said I was ready. I was eating healthier, working out regularly, and sleeping consistently. I would never have done this without her support. This wasn’t the typical bipolar action of, “Hey, I’m going off all my meds!” It was something that took years in the making. It wasn’t a decision anyone took lightly.

It took time to adjust. I needed to actively monitor my stress levels. I needed to remember to slow down and rest. I took my supplements diligently. I ran. A year and a half later, I found yoga.

Today I feel better than I ever have.

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Continue reading “Being Med-Free: My 4 Year Anniversary”